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Epidemiology
Serum 25-Hydroxyvitamin D Concentration Is Independently Inversely Associated with Insulin Resistance in the Healthy, Non-Obese Korean Population
So Young Ock, Kyoung Hwa Ha, Bu Kyung Kim, Hyeon Chang Kim, Jee-Seon Shim, Myung Ha Lee, Young Me Yoon, Dae Jung Kim
Diabetes Metab J. 2016;40(5):367-375.   Published online July 26, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.5.367
  • 3,735 View
  • 31 Download
  • 9 Web of Science
  • 9 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

We evaluated the associations between 25-hydroxyvitamin D (25(OH)D) concentrations in serum and insulin resistance in the healthy Korean population.

Methods

We conducted this cross-sectional analysis in 1,807 healthy Korean people (628 men and 1,179 women) aged 30 to 64 years in the Cardiovascular and Metabolic Disease Etiologic Research Center study. All participants were assessed for 25(OH)D, fasting glucose, and insulin levels, and completed a health examination and lifestyle questionnaire according to standard procedures. Insulin resistance was defined as the homeostasis model assessment insulin resistance higher than the 75 percentile.

Results

Compared to those in the highest tertile (≥14.3 ng/mL), the odds ratio (OR) for insulin resistance was 1.37 (95% confidence interval [CI], 1.01 to 1.86) for the 1st tertile (<9.7 ng/mL) and 1.19 (95% CI, 0.08 to 1.62) for the 2nd tertile (9.7 to 14.3 ng/mL) after adjusting for age, gender, waist circumference, alcohol consumption, smoking status, physical exercise, season, and cohort. After stratification of the subjects by adiposity, these associations remained only in non-obese subjects (lowest tertile vs. highest tertile, multivariable OR, 1.64; 95% CI, 1.05 to 2.56).

Conclusion

Serum 25(OH)D has an independent inverse association with insulin resistance in the healthy, non-obese Korean population, even among people with vitamin D insufficiency.

Citations

Citations to this article as recorded by  
  • Vitamin D and Cardiovascular Diseases: An Update
    Farrookh Haider, Hashsaam Ghafoor, Omar F Hassan, Khalid Farooqui, Ali O. Mohamed Bel Khair, Faryal Shoaib
    Cureus.2023;[Epub]     CrossRef
  • Vitamin D as predictor Marker of kidney disease in males with type 2 diabetes mellitus
    Abeer J. Hassan, Sarmad Ajeel Hazzaa, Dunya Najim Alden Ahmed
    Bionatura.2022; 7(2): 1.     CrossRef
  • Vitamin D Effect on Ultrasonography and Laboratory Indices and Biochemical Indicators in the Blood: an Interventional Study on 12 to 18-Year-Old Children with Fatty Liver
    Kokab Namakin, Mahya Hosseini, Mahmoud Zardast, Mahyar Mohammadifard
    Pediatric Gastroenterology, Hepatology & Nutrition.2021; 24(2): 187.     CrossRef
  • The Association between Vitamin D and Nonalcoholic Fatty Liver Disease Assessed by Controlled Attenuation Parameter
    Nam Ju Heo, Hyo Eun Park, Ji Won Yoon, Min-Sun Kwak, Jong In Yang, Su Jin Chung, Jeong Yoon Yim, Goh Eun Chung
    Journal of Clinical Medicine.2021; 10(12): 2611.     CrossRef
  • Association between serum 25-hydroxy vitamin D level and metabolic associated fatty liver disease (MAFLD)—a population-based study
    Bo Wan, Yuan Gao, Yushan Zheng, Ruanqin Chen
    Endocrine Journal.2021; 68(6): 631.     CrossRef
  • Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience
    Vincenzo Pilone, Salvatore Tramontano, Carmen Cutolo, Federica Marchese, Antonio Maria Pagano, Federica Di Spirito, Luigi Schiavo
    International Journal for Vitamin and Nutrition Research.2020; 90(3-4): 346.     CrossRef
  • Cohort Profile: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort in Korea
    Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Yoosik Youm, Eui-Cheol Shin, Hyeon Chang Kim
    Yonsei Medical Journal.2019; 60(8): 804.     CrossRef
  • Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort: study protocol and results of the first 3 years of enrollment
    Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Hyeon Chang Kim
    Epidemiology and Health.2017; 39: e2017016.     CrossRef
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    Dae Jung Kim
    Osteoporosis and Sarcopenia.2017; 3(4): 201.     CrossRef
Prevalence of Dyslipidemia among Korean Adults: Korea National Health and Nutrition Survey 1998-2005
Myung Ha Lee, Hyeon Chang Kim, Song Vogue Ahn, Nam Wook Hur, Dong Phil Choi, Chang Gyu Park, Il Suh
Diabetes Metab J. 2012;36(1):43-55.   Published online February 17, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.1.43
  • 3,871 View
  • 38 Download
  • 60 Crossref
AbstractAbstract PDFPubReader   
Background

Dyslipidemia is a disorder of lipid metabolism, including elevated total cholesterol, elevated triglyceride, elevated low density lipoprotein cholesterol (LDL-C), and decreased high density lipoprotein cholesterol (HDL-C). The objective of this study was to investigate recent changes in the prevalence of dyslipidemia and also the rates of awareness, treatment, and control of dyslipidemia among Korean adults.

Methods

Dyslipidemia is defined according to the National Cholesterol Education Program-Adult Treatment Panel III as total cholesterol ≥240 mg/dL, LDL-C ≥160 mg/dL, HDL-C <40 mg/dL, and triglyceride ≥200 mg/dL. The prevalence of dyslipidemia was estimated for adults aged ≥20 years using the Korea National Health and Nutrition Survey (KNHANES) in 1998 (n=6,923), 2001 (n=4,882), and 2005 (n=5,323). Rates of awareness, treatment and control of dyslipidemia were calculated for adults aged ≥30 years using the KNHANES in 2005 (n=4,654).

Results

The prevalence of dyslipidemia (aged ≥20 years) increased from 32.4% in 1998 to 42.6% in 2001 and 44.1% in 2005. Compared with the KNHANES in 1998, the prevalence of dyslipidemia was 47% (95% confidence interval [CI], 35% to 59%) higher in 2001 and 61% (95% CI, 49% to 75%) higher in 2005. In 2005, only 9.5% of people with dyslipidemia were aware of the disease, 5.2% used lipid-lowering medication, and 33.2% of patients with treatment reached treatment goals.

Conclusion

The prevalence of dyslipidemia in Korea gradually increased between 1998 and 2005. These findings suggest that more intense efforts for the prevention and treatment of dyslipidemia may lead to further improvement in the management of dyslipidemia.

Citations

Citations to this article as recorded by  
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    Journal of Diabetes Investigation.2013; 4(5): 460.     CrossRef
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  • Response: Prevalence of Dyslipidemia among Korean Adults: Korea National Health and Nutrition Survey 1998-2005 (Diabetes Metab J 2012;36:43-55)
    Hyeon Chang Kim
    Diabetes & Metabolism Journal.2012; 36(2): 165.     CrossRef
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    Ross D. Feldman, Tavis S. Campbell
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  • Letter: Prevalence of Dyslipidemia among Korean Adults: Korea National Health and Nutrition Survey 1998-2005 (Diabetes Metab J 2012;36:43-55)
    Bo Kyung Koo
    Diabetes & Metabolism Journal.2012; 36(2): 163.     CrossRef

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